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Plot Summary:Some things never change: Ame no Kisaki, that famous and extraordinarily exclusive boarding school, STILL doesn’t accept boys. And Kanako, Kisaki’s most romantically unfortunate student, STILL doesn’t accept them either. They give her the hives. Literally. Sadly, that means that Kanako’s STILL trying to connect with ANYONE of the same sex , and having the usual horrid luck; STILL being in imminent peril of dying from the constant nosebleeds she gets from being over stimulated by the presence of her fellow classmates; and STILL being forced to endure the tragedy of sharing a room with the school’s most beautiful girl, who is, of course, STILL a guy in drag. Poor Kanako! She came to school to major in loving women, and instead she’s STILL failing relationships in Maria Holic Alive!

The story centers on a sophomore named Kanako who enrolls in all-girls school because she has a phobia of men and wants to find her destined yuri partner. She meets a captivating freshman named Mariya who fits her criteria — except her seemingly ideal mate happens to be a cross-dressing sadistic boy.